Ontology highlight
ABSTRACT:
SUBMITTER: Szymura SJ
PROVIDER: S-EPMC6421657 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Szymura Szymon J SJ Zaemes Jacob P JP Allison David F DF Clift Sheena H SH D'Innocenzi Jaclyn M JM Gray Lisa G LG McKenna Brian D BD Morris Benjamin B BB Bekiranov Stefan S LeGallo Robin D RD Jones David R DR Mayo Marty W MW
Cell communication and signaling : CCS 20190318 1
<h4>Background</h4>Epithelial-to-mesenchymal transition (EMT) results in changes that promote de-differentiation, migration, and invasion in non-small cell lung cancer (NSCLC). While it is recognized that EMT promotes altered energy utilization, identification of metabolic pathways that link EMT with cancer progression is needed. Work presented here indicates that mesenchymal NSCLC upregulates glutamine-fructose-6-phosphate transaminase 2 (GFPT2). GFPT2 is the rate-limiting enzyme in the synthes ...[more]