Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses.
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ABSTRACT:
SUBMITTER: Rivera-Serrano EE
PROVIDER: S-EPMC6422491 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Cellular entry and uncoating of naked and quasi-enveloped human hepatoviruses.
Rivera-Serrano Efraín E EE González-López Olga O Das Anshuman A Das Anshuman A Lemon Stanley M SM
eLife 20190225
Many 'non-enveloped' viruses, including hepatitis A virus (HAV), are released non-lytically from infected cells as infectious, quasi-enveloped virions cloaked in host membranes. Quasi-enveloped HAV (eHAV) mediates stealthy cell-to-cell spread within the liver, whereas stable naked virions shed in feces are optimized for environmental transmission. eHAV lacks virus-encoded surface proteins, and how it enters cells is unknown. We show both virion types enter by clathrin- and dynamin-dependent endo ...[more]
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