Ontology highlight
ABSTRACT:
SUBMITTER: Naka A
PROVIDER: S-EPMC6422636 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Naka Alexander A Veit Julia J Shababo Ben B Chance Rebecca K RK Risso Davide D Stafford David D Snyder Benjamin B Egladyous Andrew A Chu Desiree D Sridharan Savitha S Mossing Daniel P DP Paninski Liam L Ngai John J Adesnik Hillel H
eLife 20190318
The neocortex is functionally organized into layers. Layer four receives the densest bottom up sensory inputs, while layers 2/3 and 5 receive top down inputs that may convey predictive information. A subset of cortical somatostatin (SST) neurons, the Martinotti cells, gate top down input by inhibiting the apical dendrites of pyramidal cells in layers 2/3 and 5, but it is unknown whether an analogous inhibitory mechanism controls activity in layer 4. Using high precision circuit mapping, in vivo ...[more]