Ontology highlight
ABSTRACT:
SUBMITTER: Malik R
PROVIDER: S-EPMC6825152 | biostudies-literature | 2019 Nov
REPOSITORIES: biostudies-literature
Malik Ruchi R Pai Emily Ling-Lin EL Rubin Anna N AN Stafford April M AM Angara Kartik K Minasi Petros P Rubenstein John L JL Sohal Vikaas S VS Vogt Daniel D
Nature communications 20191101 1
Medial ganglionic eminence (MGE)-derived somatostatin (SST)+ and parvalbumin (PV)+ cortical interneurons (CINs), have characteristic molecular, anatomical and physiological properties. However, mechanisms regulating their diversity remain poorly understood. Here, we show that conditional loss of the Tuberous Sclerosis Complex (TSC) gene, Tsc1, which inhibits the mammalian target of rapamycin (MTOR), causes a subset of SST+ CINs, to express PV and adopt fast-spiking (FS) properties, characteristi ...[more]