Putting Mucins on the Map.
Ontology highlight
ABSTRACT:
SUBMITTER: Bonser LR
PROVIDER: S-EPMC6423107 | biostudies-literature |
REPOSITORIES: biostudies-literature
Similar Datasets
Project description:Beta-diversity, the change in species composition between places, is a critical but poorly understood component of biological diversity. Patterns of beta-diversity provide information central to many ecological and evolutionary questions, as well as to conservation planning. Yet beta-diversity is rarely studied across large extents, and the degree of similarity of patterns among taxa at such scales remains untested. To our knowledge, this is the first broad-scale analysis of cross-taxon congruence in beta-diversity, and introduces a new method to map beta-diversity continuously across regions. Congruence between amphibian, bird, and mammal beta-diversity in the Western Hemisphere varies with both geographic location and spatial extent. We demonstrate that areas of high beta-diversity for the three taxa largely coincide, but areas of low beta-diversity exhibit little overlap. These findings suggest that similar processes lead to high levels of differentiation in amphibian, bird, and mammal assemblages, while the ecological and biogeographic factors influencing homogeneity in vertebrate assemblages vary. Knowledge of beta-diversity congruence can help formulate hypotheses about the mechanisms governing regional diversity patterns and should inform conservation, especially as threat from global climate change increases.
| S-EPMC2001212 | biostudies-literature
Project description:Nitric oxide radical (NO) is a signaling molecule involved in several physiological and pathological processes and a new nitrate-nitrite-NO pathway has emerged as a physiological alternative to the "classic" pathway of NO formation from L-arginine. Since the late 1990s, it has become clear that nitrite can be reduced back to NO under hypoxic/anoxic conditions and exert a significant cytoprotective action in vivo under challenging conditions. To reduce nitrite to NO, mammalian cells can use different metalloproteins that are present in cells to perform other functions, including several heme proteins and molybdoenzymes, comprising what we denominated as the "non-dedicated nitrite reductases". Herein, we will review the current knowledge on two of those "non-dedicated nitrite reductases", the molybdoenzymes xanthine oxidoreductase and aldehyde oxidase, discussing the in vitro and in vivo studies to provide the current picture of the role of these enzymes on the NO metabolism in humans.
| S-EPMC6129670 | biostudies-literature
Project description:Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins. Secreted mucins are the main component of mucus protecting the epithelia whereas membrane-bound mucins are thought to play important biological roles in cell-cell and cell-matrix interactions, in cell signaling and in modulating biological properties of cancer cells. In this review, we will focus on the altered expression pattern of mucins in pancreatic cancer, from the early neoplastic lesion Pancreatic Intraepithelial Neoplasia (PanIN) to invasive pancreatic carcinomas, and the molecular mechanisms (including genetic and epigenetic regulation) and signaling pathways known to control their expression. Moreover, we will discuss the recent advances about the biology of both secreted and membrane-bound mucins and their key roles in pancreatic carcinogenesis and resistance to therapy. Finally, we will discuss exciting opportunities that mucins offer as potential therapeutic targets in pancreatic cancer.
| S-EPMC3840449 | biostudies-literature
Project description:Generating the barriers that protect our inner surfaces from bacteria and other challenges requires large glycoproteins called mucins. These come in two types, gel-forming and transmembrane, all characterized by large, highly O-glycosylated mucin domains that are diversely decorated by Golgi glycosyltransferases to become extended rodlike structures. The general functions of mucins on internal epithelial surfaces are to wash away microorganisms and, even more importantly, to build protective barriers. The latter function is most evident in the large intestine, where the inner mucus layer separates the numerous commensal bacteria from the epithelial cells. The host's conversion of MUC2 to the outer mucus layer allows bacteria to degrade the mucin glycans and recover the energy content that is then shared with the host. The molecular nature of the mucins is complex, and how they construct the extracellular complex glycocalyx and mucus is poorly understood and a future biochemical challenge.
| S-EPMC8442341 | biostudies-literature
Project description:TP53 is the most frequently mutated gene in human cancer. Functionally, p53 is activated by a host of stress stimuli and, in turn, governs an exquisitely complex anti-proliferative transcriptional program that touches upon a bewildering array of biological responses. Despite the many unveiled facets of the p53 network, a clear appreciation of how and in what contexts p53 exerts its diverse effects remains unclear. How can we interpret p53's disparate activities and the consequences of its dysfunction to understand how cell type, mutation profile, and epigenetic cell state dictate outcomes, and how might we restore its tumor-suppressive activities in cancer?
| S-EPMC5743327 | biostudies-literature
Project description:Every molecular player in the cast of biology's central dogma is being sequenced and quantified with increasing ease and coverage. To bring the resulting genomic, transcriptomic, and proteomic data sets into coherence, tools must be developed that do not constrain data acquisition and analytics in any way but rather provide simple links across previously acquired data sets with minimal preprocessing and hassle. Here we present such a tool: PGx, which supports proteogenomic integration of mass spectrometry proteomics data with next-generation sequencing by mapping identified peptides onto their putative genomic coordinates.
| S-EPMC4782174 | biostudies-other
Project description:In a field where structure has finally begun to have a real impact, a series of new structures over the last two years have further extended our understanding of some of the critical regulatory events of the complement system. Notably, information has begun to flow from larger assemblies of components which allow insight into the often transient assemblies critical to complement regulation at the cell surface. This review will summarise the key structures determined since the last International Complement Workshop and the insights these have given us, before highlighting some questions that still require molecular frameworks to drive understanding.
| S-EPMC3664973 | biostudies-literature
Project description: Not available
| S-EPMC1463949 | biostudies-literature
Project description: Not available
| S-EPMC8374961 | biostudies-literature
Project description:The purpose of this paper is to examine, whether and under which conditions humans are able to predict the putting distance of a robotic device. Based on the "flash-lag effect" (FLE) it was expected that the prediction errors increase with increasing putting velocity. Furthermore, we hypothesized that the predictions are more accurate and more confident if human observers operate under full vision (F-RCHB) compared to either temporal occlusion (I-RCHB) or spatial occlusion (invisible ball, F-RHC, or club, F-B). In two experiments, 48 video sequences of putt movements performed by a BioRob robot arm were presented to thirty-nine students (age: 24.49±3.20 years). In the experiments, video sequences included six putting distances (1.5, 2.0, 2.5, 3.0, 3.5, and 4.0 m; experiment 1) under full versus incomplete vision (F-RCHB versus I-RCHB) and three putting distances (2. 0, 3.0, and 4.0 m; experiment 2) under the four visual conditions (F-RCHB, I-RCHB, F-RCH, and F-B). After the presentation of each video sequence, the participants estimated the putting distance on a scale from 0 to 6 m and provided their confidence of prediction on a 5-point scale. Both experiments show comparable results for the respective dependent variables (error and confidence measures). The participants consistently overestimated the putting distance under the full vision conditions; however, the experiments did not show a pattern that was consistent with the FLE. Under the temporal occlusion condition, a prediction was not possible; rather a random estimation pattern was found around the centre of the prediction scale (3 m). Spatial occlusion did not affect errors and confidence of prediction. The experiments indicate that temporal constraints seem to be more critical than spatial constraints. The FLE may not apply to distance prediction compared to location estimation.
| S-EPMC8064581 | biostudies-literature