Ontology highlight
ABSTRACT:
SUBMITTER: Liu YJ
PROVIDER: S-EPMC6424468 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Liu Yasmine J YJ Janssens Georges E GE McIntyre Rebecca L RL Molenaars Marte M Kamble Rashmi R Gao Arwen W AW Jongejan Aldo A Weeghel Michel van MV MacInnes Alyson W AW Houtkooper Riekelt H RH
PLoS genetics 20190307 3
The deregulation of metabolism is a hallmark of aging. As such, changes in the expression of metabolic genes and the profiles of amino acid levels are features associated with aging animals. We previously reported that the levels of most amino acids decline with age in Caenorhabditis elegans (C. elegans). Glycine, in contrast, substantially accumulates in aging C. elegans. In this study we show that this is coupled to a decrease in gene expression of enzymes important for glycine catabolism. We ...[more]