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Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues.

ABSTRACT: Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies.

SUBMITTER: Kruger F

PROVIDER: S-EPMC6425433 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Nucleic Acids as a Nature-Inspired Scaffold for Macromolecular Prodrugs of Nucleoside Analogues.

Krüger Franziska F Kumar Vipin V Monge Pere P Conzelmann Carina C Smith Nikaïa N Gothelf Kurt V KV Tolstrup Martin M Münch Jan J Zelikin Alexander N AN

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 20190128 6

Macromolecular prodrugs (MP) built on the natural phosphodiester and deoxyribose backbone are developed using marketed antiviral nucleoside analogues. These MP are synthesized using automated synthesis, have defined molecular composition, and have a natural mechanism for drug release. These unique attributes, coupled to the efficient cell entry and potent antiviral effects, position the prodrugs scaffolded on nucleic acids favorably for translational studies. ...[more]

PMID: 30937274

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