Ontology highlight
ABSTRACT:
SUBMITTER: Henke H
PROVIDER: S-EPMC4976076 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Henke Helena H Kryeziu Kushtrim K Banfić Jelena J Theiner Sarah S Körner Wilfried W Brüggemann Oliver O Berger Walter W Keppler Bernhard K BK Heffeter Petra P Teasdale Ian I
Macromolecular bioscience 20160512 8
The preparation of novel macromolecular prodrugs via the conjugation of two platinum(IV) complexes to suitably functionalized poly(organo)phosphazenes is presented. The inorganic/organic polymers provide carriers with controlled dimensions due to the use of living cationic polymerization and allow the preparation of conjugates with excellent aqueous solubility but long-term hydrolytic degradability. The macromolecular Pt(IV) prodrugs are designed to undergo intracellular reduction and simultaneo ...[more]