Ontology highlight
ABSTRACT:
SUBMITTER: Pan J
PROVIDER: S-EPMC6426714 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Pan Jianxin J Wang Li L Lu Charles C Zhu Yanming Y Min Zhunyuan Z Dong Xi X Sha Hongying H
iScience 20190305
Mitochondrial DNA (mtDNA) segregation associated with donor-recipient mtDNA mismatch in mitochondria replacement therapy leads to unknown risks. Here, to explore whether matching mtDNA haplotypes contributes to ameliorating segregation, we reproduced various degrees of heteroplasmic mice with three single nucleotide polymorphisms to monitor segregation severity. "Segregation" presented in tissues of heteroplasmic mice containing low-level donor mtDNA heteroplasmy, and disappeared as donor mtDNA ...[more]