Ontology highlight
ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC7337505 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Chen Zhe Z Wang Zong-Heng ZH Zhang Guofeng G Bleck Christopher K E CKE Chung Dillon J DJ Madison Grey P GP Lindberg Eric E Combs Christian C Balaban Robert S RS Xu Hong H
The Journal of cell biology 20200701 7
Although mitochondrial DNA (mtDNA) is prone to accumulate mutations and lacks conventional DNA repair mechanisms, deleterious mutations are exceedingly rare. How the transmission of detrimental mtDNA mutations is restricted through the maternal lineage is debated. Here, we demonstrate that mitochondrial fission, together with the lack of mtDNA replication, segregate mtDNA into individual organelles in the Drosophila early germarium. After mtDNA segregation, mtDNA transcription begins, which acti ...[more]