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Searching for the Role of the IFN? rs2430561 Polymorphism in Inducible Inflammation: Contribution to Metabolic Syndrome in 45 to 60-Year-Old Women.


ABSTRACT: Metabolic syndrome (MetS) is a cluster of conditions, increasing the risk of developing diseases that can lead to premature death. Interferon ?-inducible (the production of which is dependent on the IFN? rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the IFN? gene polymorphisms and serum levels of markers of interferon-gamma (IFN?)-inducible inflammatory cascade. The study sample consisted of 416 women, including 118 (28.4%) with MetS. The research procedure involved interview, anthropometric measurements, and blood collection. Kynurenine levels were significantly higher in the group of women with MetS. In the group with MetS, the A/T genotype of the IFN? gene was accompanied by higher kynurenine levels. A direct relationship between the IFN? gene polymorphisms and the rest of the markers of IFN?-inducible inflammatory cascade was not confirmed with regard to MetS in 45 to 60-year-old women. A disparity in the kynurenine level, as well as the relationship between the presence of the A/T genotype of the IFN? gene and a higher level of kynurenine in the group of women with MetS, may indicate an association between inflammation, metabolic disorders and tryptophan-kynurenine inflammatory cascade.

SUBMITTER: Szkup M 

PROVIDER: S-EPMC6427472 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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Searching for the Role of the <i>IFNγ</i> rs2430561 Polymorphism in Inducible Inflammation: Contribution to Metabolic Syndrome in 45 to 60-Year-Old Women.

Szkup Małgorzata M   Owczarek Aleksander Jerzy AJ   Lubkowska Anna A   Chełmecka Elżbieta E   Skonieczna-Żydecka Karolina K   Grochans Elżbieta E  

International journal of environmental research and public health 20190311 5


Metabolic syndrome (MetS) is a cluster of conditions, increasing the risk of developing diseases that can lead to premature death. Interferon γ-inducible (the production of which is dependent on the <i>IFNγ</i> rs2430561 polymorphism) tryptophan-kynurenine inflammatory cascade helps to understand the increased association between inflammatory process and MetS, which is why we seek the relationship between the <i>IFNγ</i> gene polymorphisms and serum levels of markers of interferon-gamma (IFNγ)-i  ...[more]

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