Stochastic modelling reveals mechanisms of metabolic heterogeneity.
Ontology highlight
ABSTRACT:
SUBMITTER: Tonn MK
PROVIDER: S-EPMC6428880 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Stochastic modelling reveals mechanisms of metabolic heterogeneity.
Tonn Mona K MK Thomas Philipp P Barahona Mauricio M Oyarzún Diego A DA
Communications biology 20190321
Phenotypic variation is a hallmark of cellular physiology. Metabolic heterogeneity, in particular, underpins single-cell phenomena such as microbial drug tolerance and growth variability. Much research has focussed on transcriptomic and proteomic heterogeneity, yet it remains unclear if such variation permeates to the metabolic state of a cell. Here we propose a stochastic model to show that complex forms of metabolic heterogeneity emerge from fluctuations in enzyme expression and catalysis. The ...[more]
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