Ontology highlight
ABSTRACT:
SUBMITTER: Willer J
PROVIDER: S-EPMC6429218 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Willer Johanna J Jöhrer Karin K Greil Richard R Zidorn Christian C Çiçek Serhat Sezai SS
Molecules (Basel, Switzerland) 20190228 5
In our continuing search for new cytotoxic agents, we assayed extracts, fractions, and pure compounds from damiana (<i>Turnera diffusa</i>) against multiple myeloma (NCI-H929, U266, and MM1S) cell lines. After a first liquid-liquid solvent extraction, the ethyl acetate layer of an acetone (70%) crude extract was identified as the most active fraction. Further separation of the active fraction led to the isolation of naringenin (<b>1</b>), three apigenin coumaroyl glucosides <b>2</b>⁻<b>4</b>, an ...[more]