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New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of Chrysanthemum morifolium and Their Bioactivities.

ABSTRACT: The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (1, 2), a new flavanone glycoside (3), and six reported flavanones (4?9) were isolated and identified from the flowers of C. morifolium. The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previously reported data. The isolated constituents 1?8 were evaluated for their neuroprotective activity, and compounds 3 and 4 displayed neuroprotective effects against hydrogen peroxide-induced neurotoxicity in human neuroblastoma SH-SY5Y cells.

SUBMITTER: Yang PF

PROVIDER: S-EPMC6429231 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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New Caffeoylquinic Acid Derivatives and Flavanone Glycoside from the Flowers of Chrysanthemum morifolium and Their Bioactivities.

Yang Peng-Fei PF Yang Ya-Nan YN He Chun-Yu CY Chen Zhi-Fei ZF Yuan Qi-Shan QS Zhao Sheng-Chen SC Fu Yu-Feng YF Zhang Pei-Cheng PC Mao Duo-Bin DB

Molecules (Basel, Switzerland) 20190228 5

The Chrysanthemum morifolium flower is widely used in China and Japan as a food, beverage, and medicine for many diseases. In our work, two new caffeoylquinic acid derivatives (1, 2), a new flavanone glycoside (3), and six reported flavanones (4⁻9) were isolated and identified from the flowers of C. morifolium. The chemical structures of all isolates were elucidated by the analysis of comprehensive spectroscopic data as well as by comparison with previou ...[more]

PMID: 30823375

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