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The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy.

ABSTRACT: Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner?Wadsworth?Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale.

SUBMITTER: Wang B

PROVIDER: S-EPMC6429350 | biostudies-literature | 2019 Mar

REPOSITORIES: biostudies-literature

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The First Total Synthesis of (±)-Methyl Salvianolate A Using a Convergent Strategy.

Wang Bo B Wang Liping L Peng Ying Y Pang Yiying Y Xiao Hesheng H Wang Xiaoji X Huang Shuangping S

Molecules (Basel, Switzerland) 20190312 5

Herein, a convergent, practicable and first total synthesis of the natural product, (±)-methyl salvianolate A, is reported. The key features of the approach are the use of a Horner⁻Wadsworth⁻Emmons reaction and the protection of multiple hydroxyls using silyl protecting groups. The employment of the readily removable silyl protecting groups allows the synthesis of (±)-methyl salvianolate A and its derivatives on a reasonably large scale. ...[more]

PMID: 30871115

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