Ontology highlight
ABSTRACT:
SUBMITTER: Trujillo M
PROVIDER: S-EPMC6429464 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Molecules (Basel, Switzerland) 20190310 5
Successful copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reactions may be achieved by several methods. In this paper, four synthetic protocols were performed for direct comparison of time required for the synthesis, yield, and purity of the 1<i>H</i>-1,2,3-triazole products. The methods with Cu(I) catalysts were conventional, microwave heating, solvent-free, and a method using glycerol solvent. The compounds synthesized in this paper were known non-fluorinated triazoles and new fluorina ...[more]