Ontology highlight
ABSTRACT:
SUBMITTER: Saunthwal RK
PROVIDER: S-EPMC6429467 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chemical science 20190206 11
5,5-Disubstituted hydantoins, formally the cyclisation products of quaternary amino acids, were formed connectively from simple ester-derived starting materials by a one-pot tandem method. Amination of the silyl ketene acetal derivative of a methyl ester takes place by silver-catalysed addition to the N[double bond, length as m-dash]N bond of an azocarboxamide, generating a <i>N</i>-amino-<i>N</i>'-aryl urea derivative of a substituted aminoester. Treatment with a base forms an ester enolate whi ...[more]