Ontology highlight
ABSTRACT:
SUBMITTER: Khayrani AC
PROVIDER: S-EPMC6429518 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Khayrani Apriliana Cahya AC Mahmud Hafizah H Oo Aung Ko Ko AKK Zahra Maram H MH Oze Miharu M Du Juan J Alam Md Jahangir MJ Afify Said M SM Quora Hagar A Abu HAA Shigehiro Tsukasa T Calle Anna Sanchez AS Okada Nobuhiro N Seno Akimasa A Fujita Koki K Hamada Hiroki H Seno Yuhki Y Mandai Tadakatsu T Seno Masaharu M
International journal of molecular sciences 20190227 5
Paclitaxel (PTX) is one of the front-line drugs approved for the treatment of ovarian cancer. However, the application of PTX is limited due to the significant hydrophobicity and poor pharmacokinetics. We previously reported target-directed liposomes carrying tumor-selective conjugated antibody and encapsulated glycosylated PTX (gPTX-L) which successfully overcome the PTX limitation. The tubulin stabilizing activity of gPTX was equivalent to that of PTX while the cytotoxic activity of gPTX was r ...[more]