Ontology highlight
ABSTRACT:
SUBMITTER: Qin J
PROVIDER: S-EPMC6429596 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chemical science 20190129 11
The catalytic enantioselective intramolecular C(sp<sup>3</sup>)-H amination of aliphatic azides represents an efficient method for constructing chiral saturated cyclic amines which constitute a prominent structural motif in bioactive compounds. We report a dual catalytic system involving a chiral-at-metal bis(pyridyl-NHC) ruthenium complex and tris(4-fluorophenyl)phosphine (both 1 mol%), which facilitates the cyclization of aliphatic azides to chiral α-aryl pyrrolidines with enantioselectivities ...[more]