Ontology highlight
ABSTRACT:
SUBMITTER: Wang L
PROVIDER: S-EPMC6431082 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wang Li L Talwar Vaishali V Osakada Takuya T Kuang Amy A Guo Zhichao Z Yamaguchi Takashi T Lin Dayu D
Cell reports 20190201 7
Active defense against a conspecific aggressor is essential for survival. Previous studies revealed strong c-Fos expression in the ventrolateral part of the ventromedial hypothalamus (VMHvl) in defeated animals. Here, we examined the functional relevance and in vivo responses of the VMHvl during conspecific defense. We found that VMHvl cells expressing estrogen receptor α (Esr1) are acutely excited during active conspecific defense. Optogenetic inhibition of the cells compromised an animal's abi ...[more]