Ontology highlight
ABSTRACT:
SUBMITTER: Yang WZ
PROVIDER: S-EPMC10427655 | biostudies-literature | 2023 Aug
REPOSITORIES: biostudies-literature
Yang Wen Z WZ Xie Hengchang H Du Xiaosa X Zhou Qian Q Xiao Yan Y Zhao Zhengdong Z Jia Xiaoning X Xu Jianhui J Zhang Wen W Cai Shuang S Li Zhangjie Z Fu Xin X Hua Rong R Cai Junhao J Chang Shuang S Sun Jing J Sun Hongbin H Xu Qingqing Q Ni Xinyan X Tu Hongqing H Zheng Ruimao R Xu Xiaohong X Wang Hong H Fu Yu Y Wang Liming L Li Xi X Yang Haitao H Yao Qiyuan Q Yu Tian T Shen Qiwei Q Shen Wei L WL
Nature communications 20230815 1
Thermal homeostasis is vital for mammals and is controlled by brain neurocircuits. Yet, the neural pathways responsible for cold defense regulation are still unclear. Here, we found that a pathway from the lateral parabrachial nucleus (LPB) to the dorsomedial hypothalamus (DMH), which runs parallel to the canonical LPB to preoptic area (POA) pathway, is also crucial for cold defense. Together, these pathways make an equivalent and cumulative contribution, forming a parallel circuit. Specifically ...[more]