Renal control of disease tolerance to malaria.
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ABSTRACT:
SUBMITTER: Ramos S
PROVIDER: S-EPMC6431151 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Renal control of disease tolerance to malaria.
Ramos Susana S Carlos Ana Rita AR Sundaram Balamurugan B Jeney Viktoria V Ribeiro Ana A Gozzelino Raffaella R Bank Claudia C Gjini Erida E Braza Faouzi F Martins Rui R Ademolue Temitope Wilson TW Blankenhaus Birte B Gouveia Zélia Z Faísca Pedro P Trujillo Damian D Cardoso Sílvia S Rebelo Sofia S Del Barrio Laura L Zarjou Abolfazl A Bolisetty Subhashini S Agarwal Anupam A Soares Miguel P MP
Proceedings of the National Academy of Sciences of the United States of America 20190304 12
Malaria, the disease caused by <i>Plasmodium</i> spp. infection, remains a major global cause of morbidity and mortality. Host protection from malaria relies on immune-driven resistance mechanisms that kill <i>Plasmodium</i> However, these mechanisms are not sufficient per se to avoid the development of severe forms of disease. This is accomplished instead via the establishment of disease tolerance to malaria, a defense strategy that does not target <i>Plasmodium</i> directly. Here we demonstrat ...[more]
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