Ontology highlight
ABSTRACT:
SUBMITTER: Kothiwal D
PROVIDER: S-EPMC6431164 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Kothiwal Deepash D Laloraya Shikha S
Proceedings of the National Academy of Sciences of the United States of America 20190306 12
Cohesin is a key determinant of chromosome architecture due to its DNA binding and tethering ability. Cohesin binds near centromeres and chromosome arms and also close to telomeres, but its role near telomeres remains elusive. In budding yeast, transcription within 20 kb of telomeres is repressed, in part by the histone-modifying silent information regulator (SIR) complex. However, extensive subtelomeric repressed domains lie outside the SIR-binding region, but the mechanism of silencing in thes ...[more]