Ontology highlight
ABSTRACT:
SUBMITTER: Lyszkiewicz M
PROVIDER: S-EPMC6431647 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Frontiers in immunology 20190318
B-cell development and function depend on stage-specific signaling through the B-cell antigen receptor (BCR). Signaling and intracellular trafficking of the BCR are connected, but the molecular mechanisms of this link are incompletely understood. Here, we investigated the role of the endosomal adaptor protein and member of the LAMTOR/Ragulator complex LAMTOR2 (p14) in B-cell development. Efficient conditional deletion of LAMTOR2 at the pre-B1 stage using <i>mb1</i>-Cre mice resulted in complete ...[more]