Ontology highlight
ABSTRACT:
SUBMITTER: Schiefermeier N
PROVIDER: S-EPMC4033770 | biostudies-literature | 2014 May
REPOSITORIES: biostudies-literature
Schiefermeier Natalia N Scheffler Julia M JM de Araujo Mariana E G ME Stasyk Taras T Yordanov Teodor T Ebner Hannes L HL Offterdinger Martin M Munck Sebastian S Hess Michael W MW Wickström Sara A SA Lange Anika A Wunderlich Winfried W Fässler Reinhard R Teis David D Huber Lukas A LA
The Journal of cell biology 20140519 4
Cell migration is mediated by the dynamic remodeling of focal adhesions (FAs). Recently, an important role of endosomal signaling in regulation of cell migration was recognized. Here, we show an essential function for late endosomes carrying the p14-MP1 (LAMTOR2/3) complex in FA dynamics. p14-MP1-positive endosomes move to the cell periphery along microtubules (MTs) in a kinesin1- and Arl8b-dependent manner. There they specifically target FAs to regulate FA turnover, which is required for cell m ...[more]