Glycoconjugate synthesis using chemoselective ligation.
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ABSTRACT:
SUBMITTER: Cheng S
PROVIDER: S-EPMC6431789 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Publications
Glycoconjugate synthesis using chemoselective ligation.
Cheng Shuihong S Wantuch Paeton L PL Kizer Megan E ME Middleton Dustin R DR Wang Ruitong R DiBello Mikaela M Li Mingli M Wang Xing X Li Xuebing X Ramachandiran Vasanthi V Avci Fikri Y FY Zhang Fuming F Zhang Xing X Linhardt Robert J RJ
Organic & biomolecular chemistry 20190301 10
Chemoselective ligation of carbohydrates and polypeptides was achieved using an adipic acid dihydrazide cross-linker. The reducing end of a carbohydrate is efficiently attached to peptides in two steps, constructing a glycoconjugate in high yield and with high regioselectivity, enabling the production of homogeneous glycoconjugates. ...[more]
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