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Asymmetric synthesis of enantiopure isoxazolidinone monomers for the synthesis of ?-oligopeptides by chemoselective amide ligation.

ABSTRACT: The design and general synthesis of enantiopure isoxazolidinone monomers as precursors for the preparation of enantiopure N-terminal hydroxylamine-?(3)-oligopeptides, which may be used as reaction partners with ?-ketoacids in the decarboxylative amide ligation reaction, is described.

SUBMITTER: Juarez-Garcia ME

PROVIDER: S-EPMC3074535 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of enantiopure isoxazolidinone monomers for the synthesis of β-oligopeptides by chemoselective amide ligation.

Juarez-Garcia M Elisa ME Yu Shouyun S Bode Jeffrey W JW

Tetrahedron 20100601 26

The design and general synthesis of enantiopure isoxazolidinone monomers as precursors for the preparation of enantiopure N-terminal hydroxylamine-β(3)-oligopeptides, which may be used as reaction partners with α-ketoacids in the decarboxylative amide ligation reaction, is described. ...[more]

PMID: 21499500

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