Ontology highlight
ABSTRACT:
SUBMITTER: Gao S
PROVIDER: S-EPMC6432281 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Chemical science 20190226 12
Stereoselective synthesis of (<i>Z</i>)-α-boryl-crotylboronate is developed. Ni-catalyzed <i>Z</i>-selective alkene isomerization of α-boryl substituted homoallylboronate provided the targeted (<i>Z</i>)-crotylboronate with high selectivity. Stereoselective addition of the novel crotylboron reagent to aldehydes gave (<i>E</i>)-δ-boryl-substituted <i>syn</i>-homoallylic alcohols with excellent diastereoselectivities. The vinyl boronate unit in the products can be directly used for a subsequent C- ...[more]