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Development of Poly(?-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering.

ABSTRACT: In this study, we developed poly(?-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. ?-cyclodextrin (?CD) was grafted to hydroxyapatite (HAp) and this ?CD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the ?CD and adamantane (AD) or between ?CD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin in the ?-CD grafted HAp was also evaluated. Osteogenic differentiation of adipose-derived stromal cells (ADSCs) was examined using an alkaline phosphatase activity (ALP) assay. The results suggest that drug loaded PCL-HAp 3-D scaffolds enhances osteogenic differentiation of ADSCs.

SUBMITTER: Lee JB 

PROVIDER: S-EPMC6432564 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature

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Development of Poly(ɛ-caprolactone) Scaffold Loaded with Simvastatin and Beta-Cyclodextrin Modified Hydroxyapatite Inclusion Complex for Bone Tissue Engineering.

Lee Jung Bok JB   Kim Ji Eun JE   Bae Min Soo MS   Park Su A SA   Balikov Daniel A DA   Sung Hak-Joon HJ   Jeon Hoon Bong HB   Park Hun Kuk HK   Um Soong Ho SH   Lee Kook Sun KS   Kwon Il Keun IK  

Polymers 20160209 2

In this study, we developed poly(ɛ-caprolactone) (PCL) 3D scaffolds using a solid free form fabrication (SFF) technique. β-cyclodextrin (βCD) was grafted to hydroxyapatite (HAp) and this βCD grafted HAp was coated onto the PCL scaffold surface, followed by drug loading through an inclusion complex interaction between the βCD and adamantane (AD) or between βCD and simvastatin (SIM). The scaffold structure was characterized by scanning electron microscopy (SEM). The release profile of simvastatin  ...[more]

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