Ontology highlight
ABSTRACT:
SUBMITTER: Phillips RS
PROVIDER: S-EPMC6433470 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Phillips Ryan S RS John Tibin T TT Koizumi Hidehiko H Molkov Yaroslav I YI Smith Jeffrey C JC Smith Jeffrey C JC
eLife 20190325
An autorhythmic population of excitatory neurons in the brainstem pre-Bötzinger complex is a critical component of the mammalian respiratory oscillator. Two intrinsic neuronal biophysical mechanisms-a persistent sodium current ([Formula: see text]) and a calcium-activated non-selective cationic current ([Formula: see text])-were proposed to individually or in combination generate cellular- and circuit-level oscillations, but their roles are debated without resolution. We re-examined these roles ...[more]