Ontology highlight
ABSTRACT:
SUBMITTER: Folts CJ
PROVIDER: S-EPMC6433515 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Folts Christopher J CJ Giera Stefanie S Li Tao T Piao Xianhua X
Trends in pharmacological sciences 20190311 4
The family of adhesion G protein-coupled receptors (aGPCRs) consists of 33 members in humans. Although the majority are orphan receptors with unknown functions, many reports have demonstrated critical functions for some members of this family in organogenesis, neurodevelopment, myelination, angiogenesis, and cancer progression. Importantly, mutations in several aGPCRs have been linked to human diseases. The crystal structure of a shared protein domain, the GPCR Autoproteolysis INducing (GAIN) do ...[more]