Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia.
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ABSTRACT:
SUBMITTER: Mezzatesta C
PROVIDER: S-EPMC6433701 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Exploiting Necroptosis for Therapy of Acute Lymphoblastic Leukemia.
Mezzatesta Caterina C Bornhauser Beat C BC
Frontiers in cell and developmental biology 20190319
Escape from chemotherapy-induced apoptosis is a hallmark of drug resistance in cancer. The recent identification of alternative programmed cell death pathways opens up for possibilities to circumvent the apoptotic blockade in drug resistant cancer and eliminate malignant cells. Indeed, we have recently shown that programmed necrosis, termed necroptosis, could be triggered to induce cell death in a subgroup of primary acute lymphoblastic leukemia (ALL) including highly refractory relapsed cases. ...[more]
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