The Human Fc?RII (CD32) Family of Leukocyte FcR in Health and Disease.

ABSTRACT: Fc?Rs have been the focus of extensive research due to their key role linking innate and humoral immunity and their implication in both inflammatory and infectious disease. Within the human Fc?R family Fc?RII (activatory Fc?RIIa and Fc?RIIc, and inhibitory Fc?RIIb) are unique in their ability to signal independent of the common ? chain. Through improved understanding of the structure of these receptors and how this affects their function we may be able to better understand how to target Fc?R specific immune activation or inhibition, which will facilitate in the development of therapeutic monoclonal antibodies in patients where Fc?RII activity may be desirable for efficacy. This review is focused on roles of the human Fc?RII family members and their link to immunoregulation in healthy individuals and infection, autoimmunity and cancer.

SUBMITTER: Anania JC 

PROVIDER: S-EPMC6433993 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature