Ontology highlight
ABSTRACT:
SUBMITTER: Li L
PROVIDER: S-EPMC6434931 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Li Lili L Zhao Hui H Liu Ping P Li Chunfeng C Quanquin Natalie N Ji Xue X Sun Nina N Du Peishuang P Qin Cheng-Feng CF Lu Ning N Cheng Genhong G
Science signaling 20180619 535
Zika virus infection stimulates a type I interferon (IFN) response in host cells, which suppresses viral replication. Type I IFNs exert antiviral effects by inducing the expression of hundreds of IFN-stimulated genes (ISGs). To screen for antiviral ISGs that restricted Zika virus replication, we individually knocked out 21 ISGs in A549 lung cancer cells and identified PARP12 as a strong inhibitor of Zika virus replication. Our findings suggest that PARP12 mediated the ADP-ribosylation of NS1 and ...[more]