Ontology highlight
ABSTRACT:
SUBMITTER: Kouyama K
PROVIDER: S-EPMC6435018 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Kouyama Kenichi K Mayanagi Kouta K Nakae Setsu S Nishi Yoshisuke Y Miwa Masanao M Shirai Tsuyoshi T
Biophysics and physicobiology 20190206
PolyADP-ribosylation (PARylation) is a posttranslational modification that is involved in the various cellular functions including DNA repair, genomic stability, and transcriptional regulation. PARylation is catalyzed by the poly(ADP-ribose) polymerase (PARP) family proteins, which mainly recognize damaged DNA and initiate repair processes. PARP inhibitors are expected to be novel anticancer drugs for breast and ovarian cancers having mutation in <i>BRCA</i> tumor suppressor genes. However the s ...[more]