Ontology highlight
ABSTRACT:
SUBMITTER: Monroe TO
PROVIDER: S-EPMC6435425 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Developmental cell 20190214 6
Specialized adult somatic cells, such as cardiomyocytes (CMs), are highly differentiated with poor renewal capacity, an integral reason underlying organ failure in disease and aging. Among the least renewable cells in the human body, CMs renew approximately 1% annually. Consistent with poor CM turnover, heart failure is the leading cause of death. Here, we show that an active version of the Hippo pathway effector YAP, termed YAP5SA, partially reprograms adult mouse CMs to a more fetal and prolif ...[more]