Ontology highlight
ABSTRACT:
SUBMITTER: Su Y
PROVIDER: S-EPMC5325677 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Nature neuroscience 20170206 3
Neuronal activity-induced gene expression modulates the function and plasticity of the nervous system. It is unknown whether and to what extent neuronal activity may trigger changes in chromatin accessibility, a major mode of epigenetic regulation of gene expression. Here we compared chromatin accessibility landscapes of adult mouse dentate granule neurons in vivo before and after synchronous neuronal activation using an assay for transposase-accessible chromatin using sequencing (ATAC-seq). We ...[more]