Ontology highlight
ABSTRACT:
SUBMITTER: Querol-Vilaseca M
PROVIDER: S-EPMC6435662 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Querol-Vilaseca Marta M Colom-Cadena Martí M Pegueroles Jordi J Nuñez-Llaves Raúl R Luque-Cabecerans Joan J Muñoz-Llahuna Laia L Andilla Jordi J Belbin Olivia O Spires-Jones Tara L TL Gelpi Ellen E Clarimon Jordi J Loza-Alvarez Pablo P Fortea Juan J Lleó Alberto A
Scientific reports 20190326 1
Soluble amyloid-β (Aβ) is considered to be a critical component in the pathogenesis of Alzheimer's disease (AD). Evidence suggests that these non-fibrillar Aβ assemblies are implicated in synaptic dysfunction, neurodegeneration and cell death. However, characterization of these species comes mainly from studies in cellular or animal models, and there is little data in intact human samples due to the lack of adequate optical microscopic resolution to study these small structures. Here, to achieve ...[more]