Ontology highlight
ABSTRACT:
SUBMITTER: Stone S
PROVIDER: S-EPMC6435683 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Stone Stephen S Abreu Damien D Mahadevan Jana J Asada Rie R Kries Kelly K Graf Rolf R Marshall Bess A BA Hershey Tamara T Urano Fumihiko F
Scientific reports 20190326 1
Endoplasmic reticulum (ER) stress in beta cells is an important pathogenic component of both type 1 and type 2 diabetes mellitus, as well as genetic forms of diabetes, especially Wolfram syndrome. However, there are currently no convenient ways to assess ER stress in beta cells, raising the need for circulating ER stress markers indicative of beta cell health. Here we show that pancreatic stone protein/regenerating protein (PSP/reg) is a potential biomarker for ER stressed beta cells. PSP/reg le ...[more]