Ontology highlight
ABSTRACT:
SUBMITTER: Ivic N
PROVIDER: S-EPMC6436938 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20190226 6
Protein transport into the nucleus is mediated by transport receptors. Import of highly charged proteins, such as histone H1 and ribosomal proteins, requires a dimer of two transport receptors. In this study, we determined the cryo-EM structure of the Imp7:Impβ:H1.0 complex, showing that the two importins form a cradle that accommodates the linker histone. The H1.0 globular domain is bound to Impβ, whereas the acidic loops of Impβ and Imp7 chaperone the positively charged C-terminal tail. Althou ...[more]