Ontology highlight
ABSTRACT:
SUBMITTER: Kumar M
PROVIDER: S-EPMC6437482 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Antimicrobial agents and chemotherapy 20190327 4
DS86760016 is a new leucyl-tRNA-synthetase inhibitor at the preclinical development stage. DS86760016 showed potent activity against extended-spectrum multidrug-resistant <i>Pseudomonas aeruginosa</i> isolated from clinical samples and <i>in vitro</i> biofilms. In a murine catheter-associated urinary tract infection model, DS86760016 treatment resulted in significant eradication of <i>P. aeruginosa</i> from the kidney, bladder, and catheter without developing drug resistance. Our data suggest th ...[more]