Ontology highlight
ABSTRACT:
SUBMITTER: Zhao M
PROVIDER: S-EPMC6437555 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Zhao Mingxia M Guo Wenjie W Wu Yuanyuan Y Yang Chenxi C Zhong Liang L Deng Guoliang G Zhu Yuyu Y Liu Wen W Gu Yanhong Y Lu Yin Y Kong Lingdong L Meng Xiangbao X Xu Qiang Q Sun Yang Y
Acta pharmaceutica Sinica. B 20180905 2
Tyrosine phosphatase SHP2 is a promising drug target in cancer immunotherapy due to its bidirectional role in both tumor growth promotion and T-cell inactivation. Its allosteric inhibitor SHP099 is known to inhibit cancer cell growth both <i>in vitro</i> and <i>in vivo</i>. However, whether SHP099-mediated SHP2 inhibition retards tumor growth <i>in vivo via</i> anti-tumor immunity remains elusive. To address this, a CT-26 colon cancer xenograft model was established in mice since this cell line ...[more]