Ontology highlight
ABSTRACT:
SUBMITTER: Zhang X
PROVIDER: S-EPMC8316469 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
Zhang Xiaozhen X Huang Xing X Xu Jian J Li Enliang E Lao Mengyi M Tang Tianyu T Zhang Gang G Guo Chengxiang C Zhang Xiaoyu X Chen Wen W Yadav Dipesh Kumar DK Bai Xueli X Liang Tingbo T
Nature communications 20210727 1
Despite the substantial impact of post-translational modifications on programmed cell death 1 ligand 1 (PD-L1), its importance in therapeutic resistance in pancreatic cancer remains poorly defined. Here, we demonstrate that never in mitosis gene A-related kinase 2 (NEK2) phosphorylates PD-L1 to maintain its stability, causing PD-L1-targeted pancreatic cancer immunotherapy to have poor efficacy. We identify NEK2 as a prognostic factor in immunologically "hot" pancreatic cancer, involved in the on ...[more]