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Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction.


ABSTRACT: BACKGROUND:Stroke can lead to cardiac dysfunction in patients, but the mechanisms underlying the interaction between the injured brain and the heart are poorly understood. The objective of the study is to investigate the effects of experimental murine stroke on cardiac function and molecular signalling in the heart. METHODS AND RESULTS:Mice were subjected to filament-induced left middle cerebral artery occlusion for 30 or 60 min or sham surgery and underwent repetitive micro-echocardiography. Left ventricular contractility was reduced early (24-72 h) but not late (2 months) after brain ischaemia. Cardiac dysfunction was accompanied by a release of high-sensitive cardiac troponin (hsTNT (ng/ml): d1: 7.0?±?1.0 vs. 25.0?±?3.2*; d3: 7.3?±?1.1 vs. 52.2?±?16.7*; d14: 5.7?±?0.8 vs. 5.2?±?0.3; sham vs. 60 min. MCAO; mean ± SEM; *p?

SUBMITTER: Veltkamp R 

PROVIDER: S-EPMC6438414 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Experimental ischaemic stroke induces transient cardiac atrophy and dysfunction.

Veltkamp Roland R   Uhlmann Stefan S   Marinescu Marilena M   Sticht Carsten C   Finke Daniel D   Gretz Norbert N   Gröne Herrmann-Josef HJ   Katus Hugo A HA   Backs Johannes J   Lehmann Lorenz H LH  

Journal of cachexia, sarcopenia and muscle 20181030 1


<h4>Background</h4>Stroke can lead to cardiac dysfunction in patients, but the mechanisms underlying the interaction between the injured brain and the heart are poorly understood. The objective of the study is to investigate the effects of experimental murine stroke on cardiac function and molecular signalling in the heart.<h4>Methods and results</h4>Mice were subjected to filament-induced left middle cerebral artery occlusion for 30 or 60 min or sham surgery and underwent repetitive micro-echoc  ...[more]

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