Ontology highlight
ABSTRACT:
SUBMITTER: Simonetta KR
PROVIDER: S-EPMC6441019 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Simonetta Kyle R KR Taygerly Joshua J Boyle Kathleen K Basham Stephen E SE Padovani Chris C Lou Yan Y Cummins Thomas J TJ Yung Stephanie L SL von Soly Szerenke Kiss SK Kayser Frank F Kuriyan John J Rape Michael M Cardozo Mario M Gallop Mark A MA Bence Neil F NF Barsanti Paul A PA Saha Anjanabha A
Nature communications 20190329 1
Protein-protein interactions (PPIs) governing the recognition of substrates by E3 ubiquitin ligases are critical to cellular function. There is significant therapeutic potential in the development of small molecules that modulate these interactions; however, rational design of small molecule enhancers of PPIs remains elusive. Herein, we report the prospective identification and rational design of potent small molecules that enhance the interaction between an oncogenic transcription factor, β-Cat ...[more]