Dataset Information

Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes.

ABSTRACT:

Introduction

Type 2 diabetes is a worldwide disease which is associated with chronic, low-grade inflammation. The PD-1/PD-L1 pathway has been reported to be a negative regulatory element in immune homeostasis and to be involved in many diseases.

Materials and methods

Peripheral blood mononuclear cells (PBMCs) were obtained from type 2 diabetes patients (n = 23) and healthy donors (n = 20). The PD-L1 and PD-1 expressions on corresponding immune cells were evaluated by flow cytometry.

Results

The PD-L1 expression on corresponding immune cells has no significant difference between these two groups. We showed the downregulated PD-1 expression in type 2 diabetes patients. The correlation analysis indicated that the PD-1 on NK cells has a positive correlation with insulin and diabetes duration. And an inverse correlation has been shown between the PD-1 expression on monocytes and BMI (body mass index).

Conclusions

The results in this article suggest that PD-1, unlike PD-L1, might participate in the progression of type 2 diabetes. This investigation will provide evidence for the potential immune therapy for T2D.

SUBMITTER: Sun P

PROVIDER: S-EPMC6441514 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes.

Sun Peng P Jin Qingyan Q Nie Shengnan S Jia Shijie S Li Yuanyuan Y Li Xiaoxue X Guo Fang F

Journal of diabetes research 20190317

<h4>Introduction</h4>Type 2 diabetes is a worldwide disease which is associated with chronic, low-grade inflammation. The PD-1/PD-L1 pathway has been reported to be a negative regulatory element in immune homeostasis and to be involved in many diseases.<h4>Materials and methods</h4>Peripheral blood mononuclear cells (PBMCs) were obtained from type 2 diabetes patients (<i>n</i> = 23) and healthy donors (<i>n</i> = 20). The PD-L1 and PD-1 expressions on corresponding immune cells were evaluated by ...[more]

PMID: 31008114

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Dataset Information

Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes.

Introduction

Materials and methods

Results

Conclusions

Publications

Unlike PD-L1, PD-1 Is Downregulated on Partial Immune Cells in Type 2 Diabetes.

Similar Datasets

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