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PD-L1 immune suppression in cancer: Tumor cells or host cells?


ABSTRACT: Four recent publications reported the role of PD-L1 expression on host versus malignant cells within the tumor for PD-1/PD-L1 checkpoint blockade therapy. All four research groups harmoniously report: PD-L1 expressed by both host as well as tumor cells are capable of suppressing T cell functions. Thus, checkpoint therapy can be effective, if malignant cells do not express PD-L1.

SUBMITTER: Kleinovink JW 

PROVIDER: S-EPMC5543902 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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