Sleep modulates haematopoiesis and protects against atherosclerosis.
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ABSTRACT:
SUBMITTER: McAlpine CS
PROVIDER: S-EPMC6442744 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Sleep modulates haematopoiesis and protects against atherosclerosis.
McAlpine Cameron S CS Kiss Máté G MG Rattik Sara S He Shun S Vassalli Anne A Valet Colin C Anzai Atsushi A Chan Christopher T CT Mindur John E JE Kahles Florian F Poller Wolfram C WC Frodermann Vanessa V Fenn Ashley M AM Gregory Annemijn F AF Halle Lennard L Iwamoto Yoshiko Y Hoyer Friedrich F FF Binder Christoph J CJ Libby Peter P Tafti Mehdi M Scammell Thomas E TE Nahrendorf Matthias M Swirski Filip K FK
Nature 20190213 7744
Sleep is integral to life<sup>1</sup>. Although insufficient or disrupted sleep increases the risk of multiple pathological conditions, including cardiovascular disease<sup>2</sup>, we know little about the cellular and molecular mechanisms by which sleep maintains cardiovascular health. Here we report that sleep regulates haematopoiesis and protects against atherosclerosis in mice. We show that mice subjected to sleep fragmentation produce more Ly-6C<sup>high</sup> monocytes, develop larger ath ...[more]
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