Ontology highlight
ABSTRACT:
SUBMITTER: Choi E
PROVIDER: S-EPMC6443781 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Choi Eunhee E Kikuchi Sotaro S Gao Haishan H Brodzik Karolina K Nassour Ibrahim I Yopp Adam A Singal Amit G AG Zhu Hao H Yu Hongtao H
Nature communications 20190401 1
Insulin controls glucose homeostasis and cell growth through bifurcated signaling pathways. Dysregulation of insulin signaling is linked to diabetes and cancer. The spindle checkpoint controls the fidelity of chromosome segregation during mitosis. Here, we show that insulin receptor substrate 1 and 2 (IRS1/2) cooperate with spindle checkpoint proteins to promote insulin receptor (IR) endocytosis through recruiting the clathrin adaptor complex AP2 to IR. A phosphorylation switch of IRS1/2 orchest ...[more]