Ontology highlight
ABSTRACT:
SUBMITTER: Pokharel SM
PROVIDER: S-EPMC6443809 | biostudies-literature | 2019 Apr
REPOSITORIES: biostudies-literature
Nature communications 20190401 1
Integrins are components of cell-matrix adhesions, and function as scaffolds for various signal transduction pathways. So far no lipid ligand for integrin has been reported. Here we show that a lipid, oxysterol 25-hydroxycholesterol (25HC), directly binds to α5β1 and αvβ3 integrins to activate integrin-focal adhesion kinase (FAK) signaling. Treatment of macrophages and epithelial cells with 25HC results in an increase in activated αvβ3 integrin in podosome and focal adhesion matrix adhesion site ...[more]